Animal Models in Traumatic Spinal Cord Injury
作者： Mahdi Sharif-Alhoseini , Vafa Rahimi-Movaghar
DOI: 10.5772/57189
关键词:
摘要: Currently, to choose an animal model, some factors are considered depending upon the proposed aim of study. Transections and contusions spinal cord most commonly used methods for modeling SCI. While transection models provide idealized setting studying regeneration across a complete lesion, but transected cords rarely encountered in human In other words, injured maintain tissue continuity area injury. But contusion compression more clinically relevant. These can create graded injuries characterized by hemorrhagic necrosis, ischemia, inflammation, central cavitation. Besides, contribute simulate persistent canal occlusion that is common SCIs.
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Gracee Agrawal, Candace Kerr, Nitish V. Thakor, Angelo H. All, Characterization of graded multicenter animal spinal cord injury study contusion spinal cord injury using somatosensory-evoked potentials. Spine. ,vol. 35, pp. 1122- 1127 ,(2010) , 10.1097/BRS.0B013E3181BE5FA7
Seyed Behzad Jazayeri, Masoumeh Firouzi, Shayan Abdollah Zadegan, Niloufar Saeedi, Elham Pirouz, Mohsen Nategh, Issa Jahanzad, Ahmad Mohebbi Ashtiani, Atefeh Yazdi, Mehrbod Karimi, Vafa Rahimi-Movaghar, The effect of timing of decompression on neurologic recovery and histopathologic findings after spinal cord compression in a rat model. Acta medica Iranica. ,vol. 51, pp. 431- 437 ,(2013)
Daniel Lammertse, David Dungan, James Dreisbach, Scott Falci, Adam Flanders, Ralph Marino, Eric Schwartz, Neuroimaging in traumatic spinal cord injury: an evidence-based review for clinical practice and research Journal of Spinal Cord Medicine. ,vol. 30, pp. 205- 214 ,(2007) , 10.1080/10790268.2007.11753928
Tator Ch, Rivlin As, Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surgical Neurology. ,vol. 10, pp. 38- 43 ,(1978)
Stanley A. Skinner, Ensor E. Transfeldt, Electromyography in the detection of mechanically induced spinal motor tract injury: observations in diverse porcine models. Journal of Neurosurgery. ,vol. 11, pp. 369- 374 ,(2009) , 10.3171/2009.3.SPINE08881
Manuel Gaviria, Henri Haton, Françoise Sandillon, Alain Privat, A Mouse Model of Acute Ischemic Spinal Cord Injury Journal of Neurotrauma. ,vol. 19, pp. 205- 221 ,(2002) , 10.1089/08977150252806965
Stephen W. Scheff, Alexander G. Rabchevsky, Isabella Fugaccia, John A. Main, James E. Lumpp, Experimental modeling of spinal cord injury: characterization of a force-defined injury device. Journal of Neurotrauma. ,vol. 20, pp. 179- 193 ,(2003) , 10.1089/08977150360547099
Serge Rossignol, Laurent Bouyer, Cécile Langlet, Dorothy Barthélemy, Connie Chau, Nathalie Giroux, Edna Brustein, Judith Marcoux, Hugues Leblond, Tomás A. Reader, Determinants of locomotor recovery after spinal injury in the cat Progress in Brain Research. ,vol. 143, pp. 163- 172 ,(2004) , 10.1016/S0079-6123(03)43016-1
Loic Lang-Lazdunski, Kohji Matsushita, Lorenz Hirt, Christian Waeber, Jean-Paul G Vonsattel, Michael A Moskowitz, None, Spinal cord ischemia. Development of a model in the mouse. Stroke. ,vol. 31, pp. 208- 213 ,(2000) , 10.1161/01.STR.31.1.208
Christian Brösamle, Andrea B. Huber, Cracking the black box – and putting it back together again: Animal models of spinal cord injury Drug Discovery Today: Disease Models. ,vol. 3, pp. 341- 347 ,(2006) , 10.1016/J.DDMOD.2006.11.006