PI3kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization

作者: Marwan Mounayar , Eirini Kefaloyianni , Brian Smith , Zhabiz Solhjou , Omar H. Maarouf

DOI: 10.1002/STEM.1986

关键词:

摘要: … STAT1 overexpressed MSC showed enhanced T‐cell suppression. Of note, unstimulated CB‐MSC overexpressing STAT1 suppressed T cells … activated T cells in the T‐cell suppression …

参考文章(40)
C.J. Vlahos, W.F. Matter, K.Y. Hui, R.F. Brown, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry. ,vol. 269, pp. 5241- 5248 ,(1994) , 10.1016/S0021-9258(17)37680-9
Christian Rommel, Montserrat Camps, Hong Ji, PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond? Nature Reviews Immunology. ,vol. 7, pp. 191- 201 ,(2007) , 10.1038/NRI2036
Maria Ester Bernardo, Willem E. Fibbe, Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders Annals of the New York Academy of Sciences. ,vol. 1266, pp. 107- 117 ,(2012) , 10.1111/J.1749-6632.2012.06667.X
Andrew L. Mellor, David H. Munn, Ido expression by dendritic cells: tolerance and tryptophan catabolism Nature Reviews Immunology. ,vol. 4, pp. 762- 774 ,(2004) , 10.1038/NRI1457
Antonio Uccelli, Lorenzo Moretta, Vito Pistoia, Mesenchymal stem cells in health and disease Nature Reviews Immunology. ,vol. 8, pp. 726- 736 ,(2008) , 10.1038/NRI2395
Andrea Augello, Roberta Tasso, Simone Maria Negrini, Ranieri Cancedda, Giuseppina Pennesi, Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen‐induced arthritis Arthritis & Rheumatism. ,vol. 56, pp. 1175- 1186 ,(2007) , 10.1002/ART.22511
J Liang, H Zhang, B Hua, H Wang, J Wang, Z Han, L Sun, Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis Multiple Sclerosis Journal. ,vol. 15, pp. 644- 646 ,(2009) , 10.1177/1352458509104590
Shahab Uddin, Beata Majchrzak, Pu-Chen Wang, Sanjiv Modi, Mohammad K. Khan, Eleanor N. Fish, Leonidas C. Platanias, Interferon-Dependent Activation of the Serine Kinase PI 3′-Kinase Requires Engagement of the IRS Pathway but Not the Stat Pathway Biochemical and Biophysical Research Communications. ,vol. 270, pp. 158- 162 ,(2000) , 10.1006/BBRC.2000.2402
Kang-Hsi Wu, Chin-Kan Chan, Chris Tsai, Yu-Hsiang Chang, Martin Sieber, Tsan-Hung Chiu, Ming Ho, Ching-Tien Peng, Han-Ping Wu, Jing-Long Huang, Effective Treatment of Severe Steroid-Resistant Acute Graft-Versus-Host Disease With Umbilical Cord-Derived Mesenchymal Stem Cells Transplantation. ,vol. 91, pp. 1412- 1416 ,(2011) , 10.1097/TP.0B013E31821ABA18