Sensitive TSH and TSH-receptor antibody determinations as predictors of relapse in Graves' disease

摘要: After primary successful antithyroid drug treatment (ATDT), Graves' disease (GD) has a relapse rate of 30 to 50%. Despite higher sensitivity and specificity the new second generation human TSH receptor assay, predictive value TRAb for hyperthyroidism is still controversial. In recent prospective multicenter study we have previously shown that suppressed or low values predict both early (persistence) late GD. We now present more detailed analysis recurrent hyperthyroidism. Four weeks after withdrawal ATDT, 96 patients were available thyroid function tests, including sensitive third assay recombinant assay. Relapse GD was evaluated total follow-up two years. Within years, 47 (49%) developed Nine relapsed within first four ATDT thus considered persistent Ten fifteen other with levels below 0.3 mU/L without overt Twenty-five 65 normal had cessation, positive 70% negative 62% (specificity 85%) Mean in group significantly (11.1 IU/L±0.17) than remission (4.5 IU/L±0.6), p<0.001. Using cut-off 1.5 IU/L, 49% 54%, respectively 14%), but level 10 improved 83% 62%, 92%). conclusion, GD, and, lesser extend, years follow-up. Also, above IU/L found small subset patients, correlated rate.