Hematological Abnormality, Oxidative Stress, and Genotoxicity Induction in the Greenhouse Pesticide Sprayers; Investigating the Role of NQO1 Gene Polymorphism

摘要: The widespread use of pesticides in agriculture represents a threat to the human populations exposed them. In this cross-sectional study, hematological and biochemical parameters, plasma cholinesterase (PChE) activity, oxidative stress, genotoxicity, NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism were measured 100 greenhouse workers occupationally pesticide mixture 104 normal healthy controls. There was decrease erythrocytes (5.45%, p = 0.026) hemoglobin (3.26%, 0.025), an increase mean corpuscular (3.54%, 0.013) workers. Sprayers showed reduction PChE (23%) GSH (50%) levels, lipid peroxidation (LPO) (55%), protein carbonyl (145%), Superoxide dismutase activity (61%), total antioxidant capacity (35%) (p < 0.001 for all parameters but LPO: 0.009). Genotoxicity significantly high cases (for parameters: tail length: 0.002). significant correlation between stress genotoxicity also these biomarkers activity. NQO1 not associated with studied biomarkers. findings indicate that occupational exposure can induce hematotoxicity,