PLASMA PROTEIN BINDING OF BUPIVACAINE AND ITS INTERACTION WITH OTHER DRUGS IN MAN

摘要: The plasma protein binding of bupivacaine in heparinized from healthy volunteers and patients receiving diphenylhydantoin, quinidine or pethidine was investigated using equilibrium dialysis technique at 4°C. mean unbound fraction normal individuals 6.3 ±0.68 (SEM) percent a concentration 1 μg/ml. decreased as the drug increased. There an increase 300–400% taken patients. addition quinidine, pethidine, desipramine, but not atropine, to also caused marked displacement bupivacaine. If this effect occurs vivo, likelihood increased local anaesthetic toxicity may be