L-selectin and alpha 4 beta 7 integrin homing receptor pathways mediate peripheral lymphocyte traffic to AKR mouse hyperplastic thymus.

摘要: Before the development of thymic lymphoma, AKR mice undergo a striking lymphoid hyperplasia medulla. We have previously shown that there is marked increase in traffic B and T lymphocytes from periphery into preneoplastic, hyperplastic thymuses these mice, contrast to scant such cells normal thymuses. The lymph nodes Peyer's patches controlled part by interaction lymphocyte adhesion molecules called homing receptors with their tissue-selective endothelial ligands known as vascular addressins. investigated roles addressins thymus. demonstrate accompanied an number medullary blood vessels high venule morphology expression peripheral node addressin (PNAd) mucosal (MAdCAM-1). In vitro vivo functional assays show addressin/homing receptor pairs PNAd/L-selectin MAdCAM-1/alpha 4 beta 7 are involved These results indicate molecular mechanisms migration tissues play role recruitment thymus thus pathogenesis hyperplasia.