Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair.

摘要: Cells are constantly exposed to oxidants from metabolic and other biochemical reactions as well external factors, suggesting that DNA repair systems nutritional antioxidants important determinants for low levels of damage cancer risk. The effects single antioxidants, various vegetables, fruits carotenoid- polyphenolic-rich products, have been assessed with biomarkers, mainly including in white blood cells (WBC), urinary excretion oxidized bases nucleosides capacity. basal oxidative damage, the interventions rather variable, possibly reflecting differences populations, regimens, type assays. In general, dose antioxidant shown protective respect WBC oxidation. Studies continuous ingestion show mixed results on WBC, due problems design, statistical power period effects. only male subjects appear consistent terms reduced pyrimidines. Investigations oxidatively stressed subjects, e.g. HIV-infected patients or diabetics, suggest beneficial outcomes populations high initial damage. Recent research effect enzymes increased removal purines, whereas mRNA relevant genes appears be unaffected by an antioxidant-rich diet. future, care should taken design intervention studies considerations gender effect, genotypes defence