Antidepressant‐like effect of ethanol extract from Paeonia lactiflora in mice
作者： Qingqiu Mao , Zhen Huang , Siupo Ip , Chuntao Che
DOI: 10.1002/PTR.2519
关键词:
摘要: The present study investigated the antidepressant effect of ethanol extract Paeonia lactiflora (EPL) in mice using forced swim test, tail suspension open-field test and reserpine test. Our results showed that intragastric administration EPL at doses 250 500 mg/kg for seven days significantly reduced duration immobility both dose was as effective positive control (chlorimipramine, 20 mg/kg) these tests. However, treatments did not affect number crossing rearing Treating with antagonized reserpine-induced ptosis hypothermia. 125 mg/kg, only hypothermia but induced by reserpine. clearly demonstrated animal models depression. action may be mediated via central monoaminergic neurotransmitter system.
sci-hub.se 参考文章(17)
P Simon, M Bourin, R Chermat, M Poncelet, The value of the reserpine test in psychopharmacology. Drug Research. ,vol. 33, pp. 1173- 1176 ,(1983)
Irina Antonijevic, Irina Antonijevic, HPA axis and sleep: identifying subtypes of major depression. Stress. ,vol. 11, pp. 15- 27 ,(2008) , 10.1080/10253890701378967
Masako Aihara, Itsuro Ida, Naoya Yuuki, Akihiko Oshima, Hiroshi Kumano, Keisuke Takahashi, Masato Fukuda, Noboru Oriuchi, Keigo Endo, Hiroshi Matsuda, Masahiko Mikuni, HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions. Psychiatry Research-neuroimaging. ,vol. 155, pp. 245- 256 ,(2007) , 10.1016/J.PSCYCHRESNS.2006.11.002
C.C. Sánchez-Mateo, C.X. Bonkanka, B. Prado, R.M. Rabanal, Antidepressant activity of some Hypericum reflexum L. fil. extracts in the forced swimming test in mice. Journal of Ethnopharmacology. ,vol. 112, pp. 115- 121 ,(2007) , 10.1016/J.JEP.2007.02.019
Ahsana Dar, Shagufta Khatoon, Antidepressant Effects of Ethanol Extract of Areca catechu in Rodents Phytotherapy Research. ,vol. 11, pp. 174- 176 ,(1997) , 10.1002/(SICI)1099-1573(199703)11:2<174::AID-PTR65>3.0.CO;2-B
Yemin Wang, Lingdong Kong, Yumei Chen, Behavioural and biochemical effects of fractions prepared from Banxia Houpu decoction in depression models in mice. Phytotherapy Research. ,vol. 19, pp. 526- 529 ,(2005) , 10.1002/PTR.1697
Lucien Steru, Raymond Chermat, Bernard Thierry, Pierre Simon, The tail suspension test: A new method for screening antidepressants in mice Psychopharmacology. ,vol. 85, pp. 367- 370 ,(1985) , 10.1007/BF00428203
M Bourin, A. J Fiocco, F Clenet, How valuable are animal models in defining antidepressant activity Human Psychopharmacology-clinical and Experimental. ,vol. 16, pp. 9- 21 ,(2001) , 10.1002/HUP.178
Hubertus Himmerich, Elisabeth B. Binder, Heike E. Künzel, Andreas Schuld, Susanne Lucae, Manfred Uhr, Thomas Pollmächer, Florian Holsboer, Marcus Ising, Successful Antidepressant Therapy Restores the Disturbed Interplay Between TNF-α System and HPA Axis Biological Psychiatry. ,vol. 60, pp. 882- 888 ,(2006) , 10.1016/J.BIOPSYCH.2006.03.075
Bin Yan, Dao-yi Wang, Dong-ming Xing, Yi Ding, Ru-feng Wang, Fan Lei, Li-jun Du, The antidepressant effect of ethanol extract of radix puerariae in mice exposed to cerebral ischemia reperfusion. Pharmacology, Biochemistry and Behavior. ,vol. 78, pp. 319- 325 ,(2004) , 10.1016/J.PBB.2004.04.010