Preparation of chitosan nanoparticles using methacrylic acid.

作者: Márcia R de Moura , Fauze A Aouada , Luiz HC Mattoso , None

DOI: 10.1016/J.JCIS.2008.02.006

关键词:

摘要: In this work the preparation of chitosan nanoparticle was investigated using methacrylic acid in different conditions and studied by particle size analyzer, zeta-potential, Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) transmission electron microscopy (TEM). The dependent on concentration used during method. Nanoparticles with sizes as small 60 nm were achieved, that can be extremely important for several applications. nanoparticles solution also pH-sensitive, due to swelling aggregation nanoparticles. obtained presented a very homogeneous morphology showing quite uniform particles distribution rather spherical shape.

参考文章(40)
C. L. de Vasconcelos, P. M. Bezerril, D. E. S. dos Santos, T. N. C. Dantas, M. R. Pereira, J. L. C. Fonseca, Effect of molecular weight and ionic strength on the formation of polyelectrolyte complexes based on poly(methacrylic acid) and chitosan. Biomacromolecules. ,vol. 7, pp. 1245- 1252 ,(2006) , 10.1021/BM050963W
A. Pohlmeier, S. Haber-Pohlmeier, Ionization of short polymethacrylic acid: titration, DLS, and model calculations. joint international conference on information sciences. ,vol. 273, pp. 369- 380 ,(2004) , 10.1016/J.JCIS.2004.02.047
Xiaohu Xia, Zhibing Hu, Manuel Marquez, Physically bonded nanoparticle networks: a novel drug delivery system Journal of Controlled Release. ,vol. 103, pp. 21- 30 ,(2005) , 10.1016/J.JCONREL.2004.11.016
Andrea Sorrentino, Giuliana Gorrasi, Vittoria Vittoria, Potential perspectives of bio-nanocomposites for food packaging applications Trends in Food Science and Technology. ,vol. 18, pp. 84- 95 ,(2007) , 10.1016/J.TIFS.2006.09.004
Magdolna Bodnar, John F. Hartmann, Janos Borbely, Preparation and Characterization of Chitosan-Based Nanoparticles Biomacromolecules. ,vol. 6, pp. 2521- 2527 ,(2005) , 10.1021/BM0502258
A KRAULAND, M ALONSO, Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system. International Journal of Pharmaceutics. ,vol. 340, pp. 134- 142 ,(2007) , 10.1016/J.IJPHARM.2007.03.005
Li Wang, Aiqin Wang, Adsorption characteristics of Congo Red onto the chitosan/montmorillonite nanocomposite. Journal of Hazardous Materials. ,vol. 147, pp. 979- 985 ,(2007) , 10.1016/J.JHAZMAT.2007.01.145
T. G. Van Thienen, K. Raemdonck, J. Demeester, S. C. De Smedt, Protein release from biodegradable dextran nanogels. Langmuir. ,vol. 23, pp. 9794- 9801 ,(2007) , 10.1021/LA700736V
Caroline Lemarchand, Ruxandra Gref, Patrick Couvreur, Polysaccharide-decorated nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 58, pp. 327- 341 ,(2004) , 10.1016/J.EJPB.2004.02.016