Therapeutic Targeting of Autophagy: Potential and Concerns in Treating Cardiovascular Disease

摘要: Autophagy is an evolutionarily conserved process by which long-lived proteins and organelles are sequestered autophagosomes subsequently degraded lysosomes for recycling. important maintaining cardiac homeostasis a survival mechanism that upregulated during stress or starvation. Accumulating evidence suggests dysregulated reduced autophagy associated with heart failure aging. Thus, modulating represents attractive future therapeutic target treating cardiovascular disease. Activation of generally considered to be cardioprotective, whereas excessive can lead cell death atrophy. It understand how regulated identify ideal targets Here, we discuss the key in core machinery describe upstream regulators respond extracellular intracellular signals tightly coordinate autophagic activity. We review various genetic pharmacological studies demonstrate role consider advantages limitations approaches modulate autophagy.