Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation.
作者： Helene Rundqvist , Randall S. Johnson , Milos Gojkovic , Pedro Veliça , Laura Barbieri
DOI: 10.3389/FIMMU.2021.633586
关键词:
摘要: Myeloid cell interactions with cells of the adaptive immune system are an essential aspect immunity. A key that interrelationship is its modulation by microenvironment. Oxygen known to influence myelosuppression T activation in part via Hypoxia inducible (HIF) transcription factors. number drugs act on HIF pathway currently clinical use and it important evaluate how they function as a better understanding will patient outcomes. We show here increased pathway, either through deletion negative regulator HIF, von Hippel-Lindau (VHL) gene, myeloid cells, or pharmacological inhibitors VHL-mediated degradation potently suppresses proliferation cell/T culture. These data demonstrate both genetic can suppress response.
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