Homing behaviour of the malignant cell clone in multiple myeloma

摘要: Multiple myeloma (MM) represents a B cell malignancy characterised by the presence of monoclonal population end-stage cells in bone marrow. Although fully matured marrow plasma are predominant type MM, there is much evidence that also more immature included malignant clone which considered to be precursor cells. The fact these detectable blood circulation and their number increases with disease progression, makes it very likely they represent component tumour mediates dissemination. This implies must have potential extravasate home environment. Like migration mechanisms used normal leukocytes and/or metastatic non-haematopoietic origin, can assumed this homing process mediated adhesive interactions chemotactic signals provided microenvironment tumour. Once compartment, will receive appropriate grow survive. aspect tumour-homing found result functional interplay between surrounding microenvironment, involving action several cytokines adhesion molecules. In end phase disease, lose stroma-dependency resulting extramedullary growth. We review discuss molecular determine behaviour MM.