Status Epilepticus in 12-day-old Rats Leads to Temporal Lobe Neurodegeneration and Volume Reduction: A Histologic and MRI Study

摘要: Summary: Purpose: Whether status epilepticus (SE) in early infancy, rather than the underlying illness, leads to temporal lobe neurodegeneration and volume reduction remains controversial. Methods: SE was induced with LiCl-pilocarpine P12 rats. To assess acute neuronal damage, brains (five controls, five SE) were investigated at 8 h after by using silver Fluoro-Jade B staining. Some from phase processed for electron microscopy. chronic changes, nine controls 13 rats analyzed 3 months histology magnetic resonance imaging (MRI). Results: MRI analysis of adult animals indicated that 23% had hippocampal, 15% amygdaloid, 31% perirhinal reduction. Histologic sections MR-imaged correlated data. Analysis both staining revealed degenerating neurons located same regions as samples. Electron microscopic irreversible ultrastructural alterations. As histologic findings, interanimal variability seen distribution severity damage. Conclusions: Our data indicate can cause hippocampus well adjacent lobe. It is likely death contributes detected a subpopulation adulthood.