Anxiety disorders in 318 bipolar patients: prevalence and impact on illness severity and response to mood stabilizer.

摘要: Objective: The aim of this study was to assess the frequency and impact anxiety disorders on illness severity response mood stabilizers in bipolar disorders. Method: 318 patients consecutively admitted psychiatric wards 2 centers as inpatients were recruited. Patients interviewed with a French version Diagnostic Interview for Genetic Studies providing DSM-IV Axis I diagnoses demographic historical characteristics. Logistic linear regressions adjust age sex performed. Results: In population mostly type (75%), 24% had at least lifetime disorder (47% these more than such disorder), 16% panic (with without agoraphobia, attacks), 11% phobia (agoraphobia disorder, social phobia, other specific phobias), 3% obsessive-compulsive disorder. Comorbidity not correlated assessed by number hospitalizations, psychotic characteristics, misuse alcohol drugs, suicide attempts (violent nonviolent). Bipolar an early onset comorbidity (p <.05). Anxiety detected frequently II patients, but difference significant =.09). responded less well anticonvulsant drugs did subjects <.05), whereas efficacy lithium similar groups. There also strong correlation between comorbid depressive temperament =.004). Conclusion: often have disorders, particularly temperament, level seems decrease drugs.