Effects of Gastrin on 3′,5′-Cyclic Adenosine Monophosphate, Intracellular Calcium, and Phosphatidylinositol Hydrolysis in Human Colon Cancer Cells

摘要: Gastrin is a trophic factor for some human colon cancer cells. However, the signal-transduction pathways by which gastrin regulates growth are still unknown. We examined effect of synthetic gastrin-17 (G-17) on and cell using 4 different lines (LoVo, COLO 320, HT-29, HCT116). G-17 stimulated production cyclic AMP in LoVo, HCT116 cells, while phosphatidylinositol hydrolysis mobilization intracellular calcium HT-29 The growth-regulatory these cells (stimulatory cells; inhibitory cells) was well correlated with pathway each line. further selective cholecystokinin-B type receptor antagonist, JMV G-17-induced G-17-regulated growth. In line, 320 that appears to regulate, at least extent, through receptor-linked cell-specific.