Saturable Fractal Pharmacokinetics and Its Applications

摘要: In this chapter we discuss an application of fractal kinetics under steady state conditions to model the enzymatic elimination a drug from body. A one-compartment following Michaelis–Menten is developed and applied concentration-time data for cardiac mibefradil in dogs. The predicts reaction order power law asymptotic time-dependence concentration. mathematical relationship between exponent derived. goodness-of-fit assessed compared that four other models suggested literature. proposed provides best fit data. addition, it correctly shape tail curve. new can be explained terms complex geometry liver, organ responsible eliminating drug. Furthermore, investigate potential identifying global characteristics pharmacokinetics anticancer paclitaxel. An analysis literature yields both clearance curves dose-dependency are accurately described by laws with similar exponents.