Predicting Coronary Heart Disease after Kidney Transplantation: Patient Outcomes in Renal Transplantation (PORT) Study

摘要: Traditional risk factors do not adequately explain coronary heart disease (CHD) after kidney transplantation. We used a large, multicenter database to compare traditional and nontraditional CHD factors, develop risk-prediction equations for transplant patients in standard clinical practice. retrospectively assessed (acute myocardial infarction, artery revascularization or sudden death) 23 575 adult from 14 centers worldwide. The cumulative incidence was 3.1%, 5.2% 7.6%, at 1, 3 5 years posttransplant, respectively. In separate Cox proportional hazards analyses of the first posttransplant year (predicted time transplant), predicted within clinic visit occurring 1–5, important included pretransplant diabetes, new onset prior pre- cardiovascular events, estimated glomerular filtration rate, delayed graft function, acute rejection, age, sex, race duration end-stage disease. performed well, with time-dependent c-statistic greater than 0.75. (e.g. hypertension, dyslipidemia cigarette smoking) added little additional predictive value. Thus, transplant-related particularly those linked much variation