摘要: In 1958 medroxyprogesterone acetate (6α-methyl,17α-acetoxyprogesterone) was first synthesized from progesterone, and in 1959 megesterol (17α-acetyloxy-6-methylpregna-4,6-diene- 3,20-dione) medroxyprogesterone. Megesterol appeared to have a strong progestational effect after both oral parenteral administration, which is thought be due its greatly increased resistance progesterone-metabolizing enzymes. The drug well absorbed the digestive tract, single dose peak plasma values are reached within 2–4 h then decline approximately 25% of value 24 h.9 males pattern urine excretion conjugated nonconjugated metabolites has been reported correspond that found women, at least 20% administered seems excreted free form.1,4
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