Inferences in microbial structural signatures of acne microbiome and mycobiome.

摘要: Acne vulgaris, commonly known as acne, is the most common skin disorder and a multifactorial disease of sebaceous gland. Although pathophysiology acne still unclear, bacterial fungal factors are to be involved in. This study aimed investigate whether microbiomes mycobiomes patients distinct from those healthy subjects identify structural signatures related vulgaris. A total 33 Korean female were recruited (Acne group, n = 17; Healthy 16), microbiome samples collected swabbing forehead right cheek. To characterize communities, 16S rRNA V4-V5 ITS1 region, respectively, sequenced analysed using Qiime2. There no significant differences in alpha beta diversities between groups. In comparison with ratio Cutibacterium Staphylococcus, had higher abundance Staphylococcus compared than individuals. network analysis dominant microorganism amplicon sequence variants (ASV) (Cutibacterium, Malassezia globosa, restricta) acnes was identified have hostile interactions globosa. Accordingly, this results suggest an insight into mycobiome controls provide possible candidates that modulate associated