Recombinant proteins of helminths with immunoregulatory properties and their possible therapeutic use

摘要: The inverse relationship between helminth infections and the development of immune-mediated diseases is a cornerstone hygiene hypothesis studies were carried out to elucidate mechanisms by which helminth-derived molecules can suppress immunological disorders. These have fostered idea that parasitic worms may be used as promising therapeutic alternative for prevention treatment diseases. We discuss current approaches identification proteins with potential immunoregulatory properties, including strategies based on high-throughput technologies. also explore methodological expression systems production recombinant forms more than 20 immunomodulatory proteins, besides their performances when evaluated immunotherapeutic treat different conditions, asthma inflammatory bowel Finally, we perspectives using these parasite-derived tools future immunotherapy immunoprophylaxis human