Ca2+ Homeostasis in Human Platelets

作者: K. S. Authi

DOI: 10.1007/978-3-642-60639-7_15

关键词:

摘要: Ca2+ is an agent of universal significance that plays a key role in triggering many platelet functions. The understanding its regulation paramount to our appreciation the mechanisms activation. complete activation by all agonists involves elevation cytosolic levels Ca2+. rise can vary from basal approximately 100nM micromolar depending upon agonist (Rink and Hallam 1984). Furthermore, direct ionophores such as A23187 which does not involve receptor occupancy results platelets.

参考文章(262)
E.V. Davies, M.B. Hallett, A Soluble Cellular Factor Directly Stimulates Ca2+ Entry in Neutrophils Biochemical and Biophysical Research Communications. ,vol. 206, pp. 348- 354 ,(1995) , 10.1006/BBRC.1995.1048
A. Zweifach, R. S. Lewis, Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 6295- 6299 ,(1993) , 10.1073/PNAS.90.13.6295
Boudewijn M.T. Burgering, Johannes L. Bos, Regulation of Ras-mediated signalling: more than one way to skin a cat Trends in Biochemical Sciences. ,vol. 20, pp. 18- 22 ,(1995) , 10.1016/S0968-0004(00)88944-6
Rainer WALDMANN, Silvia BAUER, Claus GOBEL, Franz HOFMANN, Karl H. JAKOBS, Ulrich WALTER, Demonstration of cGMP‐dependent protein kinase and cGMP‐dependent phosphorylation in cell‐free extracts of platelets FEBS Journal. ,vol. 158, pp. 203- 210 ,(1986) , 10.1111/J.1432-1033.1986.TB09739.X
Todd M. Quinton, William L. Dean, Cyclic AMP-dependent phosphorylation of the inositol-1,4,5-trisphosphate receptor inhibits Ca2+ release from platelet membranes. Biochemical and Biophysical Research Communications. ,vol. 184, pp. 893- 899 ,(1992) , 10.1016/0006-291X(92)90675-B
Nashrudeen Hack, Kalwant Singh Authi, Neville Crawford, Introduction of antibody (PL/IM 430) to a 100 kDa protein into permeabilised platelets inhibits intracellular sequestration of Ca2+. Bioscience Reports. ,vol. 8, pp. 379- 388 ,(1988) , 10.1007/BF01115229
Appavoo Rengasamy, Harold Feinberg, Inositol 1,4,5-trisphosphate-induced calcium release from platelet plasma membrane vesicles. Biochemical and Biophysical Research Communications. ,vol. 150, pp. 1021- 1026 ,(1988) , 10.1016/0006-291X(88)90731-0
Amanda B. MacKenzie, Martyn P. Mahaut-Smith, Stewart O. Sage, Activation of receptor-operated cation channels via P2X1 not P2T purinoceptors in human platelets. Journal of Biological Chemistry. ,vol. 271, pp. 2879- 2881 ,(1996) , 10.1074/JBC.271.6.2879