Highly Efficient Three‐Component Synthesis of β‐Lactams from N‐methylhydroxylamine, Aldehydes, and Phenylacetylene
作者： Liang Zhao , Chao-Jun Li
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摘要: The three-component reaction of N-substituted hydroxylamines, aldehydes, and phenylacetylene catalyzed by CuCl/2,2'-bipyridine in the presence NaOAc under neat conditions afforded corresponding beta-lactams good to excellent yields. Aromatic, heteroaromatic, aliphatic aldehydes are tolerated this reaction. electronic effects were studied for with N-methylhydroxylamine N-benzylhydroxylamine. For N-methylhydroxylamine, electron-rich provided higher yields than electron-deficient whereas N-benzylhydroxylamine, no significant effect was observed aldehydes.
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