Individual differences in transcranial electrical stimulation current density.

摘要: Transcranial electrical stimulation (TCES) is effective in treating many conditions, but it has not been possible to accurately forecast current density within the complex anatomy of a given subject's head. We sought predict and verify TCES densities determine variability these distributions patient-specific models based on magnetic resonance imaging (MRI) data. Two experiments were performed. The first experiment estimated conductivity from MRIs compared results against actual measurements scalp surface 3 subjects. In second experiment, virtual electrodes placed scalps 18 subjects model simulated with 2 mA virtually applied stimulation. This procedure was repeated for 4 electrode locations. Current then calculated 75 brain regions. Comparison modeled measured external 1 yielded correlation r = .93. 2, individual differences greatest near (ten-fold common), found all regions brain. Sites that distant (e.g. hypothalamus) typically showed two-fold differences. MRI-based modeling can effectively brains. Significant variation occurs between same configuration. Individualized should be considered place 10-20 system when accurate needed.