Injectable hyaluronic acid/PEG-p(HPMAm-lac)-based hydrogels dually cross-linked by thermal gelling and Michael addition
作者： Alessandra Dubbini , Roberta Censi , Maria Eugenia Butini , Maria Giovanna Sabbieti , Dimitrios Agas
DOI: 10.1016/J.EURPOLYMJ.2015.07.036
关键词:
摘要: Fast in situ forming thermosensitive hydrogels consisted of vinyl sulfone bearing p(HPMAm-lac(1-2))-PEG-p(HPMAm-lac(1-2)) triblock copolymers and thiol modified hyaluronic acid were prepared via a dual cross-linking strategy based on thermal gelation at 37 degrees C simultaneous Michael addition between moieties. The formation chemical network was varied within time period 9-60 min by controlling the degree derivatization, copolymer concentration thiolation. extent substitution polysaccharidic hyaluronan chain markedly affected physical mechanical properties, as well swelling degradation behavior resulting networks, confirmed rheology, water uptake experiments And tests. In addition, developed showed good cytocompatibility vitro during timeframe 21 days both for mouse bone marrow stromal cell NIH 3T3 fibroblasts. potential promising injectable biomaterials with tunable kinetics, adjustable times. These could find application regenerative matrix controlled drug delivery system. (C) 2015 Elsevier Ltd. All rights reserved.
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