Gastroenterology manifestations and COVID-19 outcomes: A meta-analysis of 25,252 cohorts among the first and second waves.

摘要: A meta-analysis was performed to identify patients with coronavirus disease 2019 (COVID-19) presenting gastrointestinal (GI) symptoms during the first and second pandemic waves investigate their association outcomes. systematic search in PubMed, Scopus, Web of Science, ScienceDirect, EMBASE up July 25, 2020. The pooled prevalence GI presentations estimated using random-effects model. Pairwise comparison for outcomes according manifestations' presentation wave infection. Data were reported as relative risk (RR), or odds ratio 95% confidence interval. Of 125 articles 25,252 patients, 20.3% presented manifestations. Anorexia (19.9%), dysgeusia/ageusia (15.4%), diarrhea (13.2%), nausea (10.3%), hematemesis (9.1%) most common. About 26.7% had confirmed positive fecal RNA, persistent viral shedding an average time 19.2 days before being negative. Patients on admission showed a higher complications, including acute respiratory distress syndrome (RR = 8.16), cardiac injury 5.36), kidney 5.52), intensive care unit (ICU) 2.56), mortality 2.01). Although not reach significant levels, subgroup-analysis revealed that affected cohorts hospitalized, ventilated, ICU admitted, expired. This suggests between COVID-19 unfavorable analysis also improved overall compared outbreak.