Trans-speciation maintenance in the MHC region of a polymorphism which includes a polymorphic dinucleotide locus, and the de novo arisal of a polymorphic tetranucleotide microsatellite.
作者： B. Crouau-Roy
DOI: 10.1034/J.1399-0039.1999.540604.X
关键词:
摘要: Alleles and the surrounding regions of DQCAR, a dinucleotide repeat tightly linked to HLA-DQB1, were sequenced in range primate species including man. Three polymorphic can usefully be defined description these sequences: GT itself, anonymous region 5' this repeat, variable CTGT 3' region. The sequence displayed six alleles individuals studied. One was invariably associated with substitutions absence others pure, repeats variation numbers repeats. Haplotypes classified by allele Those carrying 1 only found man, those 2 chimpanzee gorilla. third haplotype (indicated presence 3) chimpanzee, gorilla orang-utan, fourth gibbon, fifth baboon, guenon mangabey sixth macaque. region, but from different species, are thus often more similar than same phenomenon already shown for some HLA genes. This suggests that major histocompatibility sequences shared correlated evolutionary history. new tetranucleotide microsatellite (CTGT, 3rd region) has possibly arisen de novo pre-existing GT. study provides information not on molecular evolution particular also trans-speciation maintenance polymorphism its sequences.
sci-hub.se 参考文章(32)
Diethard Tautz, Notes on the definition and nomenclature of tandemly repetitive DNA sequences Experientia. Supplementum. ,vol. 67, pp. 21- 28 ,(1993) , 10.1007/978-3-0348-8583-6_2
V C Suraj, T L Bugawan, H A Erlich, N Fildes, G R McClure, W Klitz, R C Helmuth, A B Begovich, Polymorphism, recombination, and linkage disequilibrium within the HLA class II region. Journal of Immunology. ,vol. 148, pp. 249- 258 ,(1992)
Nelson B. Freimer, Montgomery Slatkin, Microsatellites: Evolution and Mutational Processes Ciba Foundation Symposium 197 - Variation in the Human Genome. ,vol. 197, pp. 51- 72 ,(2007) , 10.1002/9780470514887.CH4
F. J. Ayala, The myth of Eve: molecular biology and human origins. Science. ,vol. 270, pp. 1930- 1936 ,(1995) , 10.1126/SCIENCE.270.5244.1930
L L Cavalli-Sforza, M W Feldman, D B Goldstein, A Ruiz Linares, An evaluation of genetic distances for use with microsatellite loci. Genetics. ,vol. 139, pp. 463- 471 ,(1995) , 10.1093/GENETICS/139.1.463
Colette Dib, Sabine Fauré, Cécile Fizames, Delphine Samson, Nathalie Drouot, Alain Vignal, Philippe Millasseau, Sophie Marc, Jamile Kazan, Eric Seboun, Mark Lathrop, Gabor Gyapay, Jean Morissette, Jean Weissenbach, A comprehensive genetic map of the human genome based on 5,264 microsatellites Nature. ,vol. 380, pp. 152- 154 ,(1996) , 10.1038/380152A0
L. Jin, C. Macaubas, J. Hallmayer, A. Kimura, E. Mignot, Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 15285- 15288 ,(1996) , 10.1073/PNAS.93.26.15285
A. L. Hughes, M. Nei, Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 958- 962 ,(1989) , 10.1073/PNAS.86.3.958
Jan Klein, Origin of major histocompatibility complex polymorphism: The trans-species hypothesis Human Immunology. ,vol. 19, pp. 155- 162 ,(1987) , 10.1016/0198-8859(87)90066-8
WernerE. Mayer, Colm O'hUigin, Zofia Zaleska-Rutczynska, Jan Klein, Trans-species origin of Mhc-DRB polymorphism in the chimpanzee. Immunogenetics. ,vol. 37, pp. 12- 23 ,(1992) , 10.1007/BF00223540