Does comorbid bipolar disorder increase neuropsychological impairment in children and adolescents with ADHD

摘要: Objective: To assess differences in executive functioning between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) comorbid or not bipolar (BD), to study the neuropsychological profile of subjects comorbidity a clinical sample from developing country. Method: Case-control comparing 23 participants BD + ADHD 85 ADHD-only aged 6 17 years old. Both groups were drug-free. Executive function domains assessed Stroop Test, Wisconsin Card Sorting Continuous Performance Test II. Results: The group juvenile showed significantly worse performance on task, including time color (p = 0.002), color-word < 0.001), interference, number errors word cards 0.028). No between-group found other tests. Conclusions: Our findings suggest that do show inhibitory control set-shifting domains. However, greater impairment processing speed interference control. This suggests potentially higher dorsolateral prefrontal cortex may be potential signature ADHD.