Pregabalin reduces cocaine self‐administration and relapse to cocaine seeking in the rat

摘要: Pregabalin (Lyrica™) is a structural analog of γ-aminobutyric acid (GABA) and approved by the FDA for partial epilepsy, neuropathic pain generalized anxiety disorders. also reduces excitatory neurotransmitter release post-synaptic excitability. Recently, we demonstrated that pregabalin reduced alcohol intake prevented relapse to seeking elicited stress or environmental stimuli associated with availability. Here, sought extend these findings examining effect on cocaine self-administration (0.25 mg/infusion) both conditioned stress, as generated administration yohimbine (1.25 mg/kg). The results showed oral (0, 10 30 mg/kg) over an extended period (6 hours), whereas it did not modify food. In reinstatement studies, (10 abolished pharmacological stressor cues predictive Overall, demonstrate may have potential in treatment some aspects addiction.