Application of toxicogenomics to drug development.
作者： Maha M Lakkis , Marc F DeCristofaro , Hans J Ahr , Traci A Mansfield
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摘要: The application of advanced modern biomedical and chemical research technologies in the pharmaceutical industry has led to a significant increase number potential drug targets lead candidates. Whereas discovery process is enhanced significantly, failure rate new compounds due toxicity remains very high. setting high hopes on discipline toxicogenomics revolutionize assessment by reducing bottleneck candidates minimizing late-stage developmental failures. Toxicogenomics expected facilitate efficient screening at an early stage, resulting savings time cost associated with development. In this review, general description its impact safety drugs provided. An overview key issues questions that are confronting investigators field today also given as well prospective view future discipline.
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