Biosensors for in vivo glucose measurement: can we cross the experimental stage
作者： P.U Abel , T von Woedtke
DOI: 10.1016/S0956-5663(02)00099-4
关键词:
摘要: The development of in vivo working glucose sensors needs two decades, so far. availability long term functional implantable biosensors for continuous measurings is a basic preriquisite the individualized optimum insulin treatment diabetics. Enzymatic electrochemical are described which realize stability over more than 2 years vitro, however their function limited due to certain bioincompatibility expressed by inflammation surrounding tissue, exsudates, and immun reactions. paper reflects an overview concerning different sensor covering materials used as or less suitable diffusion membranes. From experimental studies animals human volunteers conclusions drawn further developmental steps use appliability transient diagnostic purposes basis controlled therapeutic measures. results demonstrate that progress aimed at biostability implanted solve technological problems serial production with really comparable qualities clinical trials.
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