Fenoldopam, but not nitroprusside, improves renal function in severely hypertensive patients with impaired renal function

摘要: Abstract purpose: Patients with hypertensive crises often experience reduced renal function that may worsen as the elevated blood pressure is treated. Fenoldopain, a novel, peripherally acting dopamine-1 agonist, lowers through arteriolar vasodilation, particularly prominent effects on vascular bed. This study was conducted to examine of fenoldopam and compared those sodium nitroprusside in severely patients impaired function. methods: Renal systemic hemodynamics were studied 19 (diastolic greater than or equal 120 mm Hg) (creatinine clearance less 70 mL/min) enrolled clinical trials nitroprusside. For comparison, an additional 22 nonimpaired under same conditions. Blood heart rate measured at baseline before treatment periodically during treatment. determined drug infusion by collection timed urine specimens samples. Creatinine clearance, flow rate, potassium excretions compared. results: In function, (mean ± SEM) successfully both groups (fenoldopam: 214 8/139 6mm Hg 176 8/107 3 Hg, p conclusion: Fenoldopam, but not nitroprusside, improved all levels while lowering pressure. Because these effects, be useful treating