Molecular mechanisms, immune cell infiltration, and potential drugs for prostate cancer.
作者： Qingyun Zhang , Mengying Bao , Yanyu Zeng , Zengnan Mo , Yunkun Yan
DOI: 10.3233/CBM-200939
关键词:
摘要: BACKGROUND The molecular mechanisms involved in the prostate cancer and their relationship with immune cell infiltration are not fully understood. patients undergoing standard androgen deprivation therapy eventually develop castration resistant (CRPC) for which there is no effective treatment currently available, hub genes this process remain unclear. OBJECTIVE To study systematically comprehensively. METHODS Differentially expressed (DEGs) of were screened Cancer Genome Atlas (TCGA) database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses performed. Connectivity Map (Cmap) software was applied to discover potential drugs. A protein-protein interaction (PPI) analysis performed obtained genes, between investigated. Next, RNAseq data hormone-sensitive samples CRPC from TCGA database further analyzed identify DEGs. Finally, a PPI obtain genes. RESULTS total 319 DEGs identified normal adjacent using comparative analysis. KEGG showed significant correlations drug metabolism, metabolism xenobiotics by cytochrome P450, chemical carcinogenesis. AMACR, FOLH1 NPY, three found be upregulated. positively correlated CD8+ T infiltration. FOLH1, NPY negatively CD4+ 426 arachidonic acid PPAR signaling pathway, AMPK metabolic pathways. top 10 network out, including PPARG, SREBF1, SCD, HMGCR, FASN, PTGS2, HMGCS2, SREBF2, FDFT1, INSIG1. Among them, SCD FASN expected therapeutic targets CRPC. CONCLUSIONS may specific diagnostic markers cancer. also closely associated Moreover, aminoglutethimide resveratrol promising drugs treating progression related other
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