GalCer Synthase (Ceramide Galactosyltransferase, CGT)
作者： Wilhelm Stoffel
DOI: 10.1007/978-4-431-67877-9_8
关键词:
摘要: The multilayer membrane system of myelin ensheathing axons the central nervous (CNS) and peripheral (PNS) is synthesized assembled by oligodendrocytes Schwann cells, respectively. lipid bilayer contributes approximately 70% to 85% total mass. composition characterized a high content cholesterol glycolipids, which galactosylceramides (cerebrosides, GalC) sulfatides, 3′-sulfoesters galactosyl-ceramides (sGalC), have been recognized as dominant components also oligodendrocyte-speciflc markers. Both are expressed in only minute amount kidney. molar ratio cholesterohphospholipids (including plasmalogen-phospholipids):galactolipids between 2:2:1 4:3:2 reasonably stable different species (human, bovine, murine myelin).
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