Combined effects of arsenic exposure and diabetes on male reproductive functions.

摘要: Background It is known that exposure to either arsenic or hyperglycemia can induce male reproductive damages. However, their combined effects on organs are still unclear. Therefore, the present study investigated morphological and functional parameters of testis, epididymis, spermatozoa in diabetic rats exposed arsenate. Materials methods Diabetes was induced by intraperitoneal streptozotocin injection. While a set healthy animals received saline solution (negative control diabetes control, respectively), other 10 mg/L sodium arsenate (arsenic + groups, respectively) for 40 days drinking water. Testosterone concentration, daily sperm production, counts testis were evaluated groups. Moreover, epididymis subjected antioxidant enzymes analysis, micromineral determination, histopathological evaluation. Results Arsenate reduced serum testosterone concentration worsened this reduction rats. In addition, number tissues, as well decreased these Sperm such motility, morphology, integrity acrosomal plasma membranes impaired health The combination arsenate, turn, increased only percentage with abnormal morphology. proportion both groups receiving Its bioaccumulation caused an imbalance activities mineral content animals, enhancing changes Testicular pathologies occurred mainly co-exposed Conclusion Our results indicate enhances several damages functions rats, impairing levels inducing nitrosative stress epididymis.