Development of a novel highly anti-proliferative family of gold complexes: Au(i)-phosphonium-phosphines.
作者： Yoann Rousselin , Ewen Bodio , François Ghiringhelli , Florence Bouyer , Myriam Laly
DOI: 10.1039/D0DT03708G
关键词:
摘要: A family of gold(I)-phosphonium-phosphine complexes was synthesized thanks to an efficient 5-step strategy, which involves a phospha-Fries rearrangement. It enables the facile variation phosphonium moiety. All along with synthetic intermediate were fully characterized (a crystal structure obtained for two them). The antiproliferative properties six novel evaluated on three human cancer cell lines (A549, MDA-MB-231, and SW480) compared those benchmark anticancer drugs used in clinics (oxaliplatin, 5-fluorouracil, paclitaxel) phosphonium-free gold(I) complex [Au(PPh3)Br]. complexes, containing phosphonium, displayed strong anti-proliferative properties. They more than oxaliplatin one even paclitaxel.
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