Comparison of Capability of Human Bone Marrow Mesenchymal Stem Cells and Endometrial Stem Cells to Differentiate into Motor Neurons on Electrospun Poly(ε-caprolactone) Scaffold.
作者： Sadegh Shirian , Somayeh Ebrahimi-Barough , Hooshang Saberi , Abbas Norouzi-Javidan , Sayed Mostafa Modarres Mousavi
DOI: 10.1007/S12035-015-9442-5
关键词:
摘要: Human endometrial and bone marrow-derived mesenchymal stem cells can be differentiated into a number of cell lineages. Mesenchymal (MSCs) are potential candidates for cellular therapy. The differentiation human marrow MSCs (hBM-MSCs) (hEnSCs) motor neuron-like has been rarely investigated previously; however, the comparison between these when they is yet to studied. aim this study was therefore investigate compare capability hBM-MSCs hEnSCs cultured on tissue culture polystyrene (TCP) poly e-caprolactone (PCL) nanofibrous scaffold differentiate in presence neural inductive molecules. Engineered seeded PCL were beta-tubulin III, islet-1, Neurofilament-H (NF-H), HB9, Pax6, choactase-positive neurons by immunostaining real-time PCR, response signaling data obtained from PCR showed that expression neuron markers both significantly higher than control group. hBM-MSCs. However, difference not statistically significant. In conclusion, provide suitable three-dimensional situation neuronal survival outgrowth regeneration central nervous system. Both may therapy disorders. better
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sci-hub.se 参考文章(34)
Shima Tavakol, Reza Saber, Elham Hoveizi, Hadi Aligholi, Jafar Ai, Seyed Mahdi Rezayat, Chimeric Self-assembling Nanofiber Containing Bone Marrow Homing Peptide's Motif Induces Motor Neuron Recovery in Animal Model of Chronic Spinal Cord Injury; an In Vitro and In Vivo Investigation. Molecular Neurobiology. ,vol. 53, pp. 3298- 3308 ,(2016) , 10.1007/S12035-015-9266-3
Mohammad Nabi Asmani, Jafar Ai, Ghasem Amoabediny, Abbas Noroozi, Mahmoud Azami, Somayeh Ebrahimi-Barough, Mona Navaei-Nigjeh, Armin Ai, Mina Jafarabadi, Three‐dimensional culture of differentiated endometrial stromal cells to oligodendrocyte progenitor cells (OPCs) in fibrin hydrogel Cell Biology International. ,vol. 37, pp. 1340- 1349 ,(2013) , 10.1002/CBIN.10171
Esmaeil Mirzaei, Jafar Ai, Somayeh Ebrahimi-Barough, Javad Verdi, Hossein Ghanbari, Reza Faridi-Majidi, The Differentiation of Human Endometrial Stem Cells into Neuron-Like Cells on Electrospun PAN-Derived Carbon Nanofibers with Random and Aligned Topographies. Molecular Neurobiology. ,vol. 53, pp. 4798- 4808 ,(2016) , 10.1007/S12035-015-9410-0
A.M. Parr, I. Kulbatski, T. Zahir, X. Wang, C. Yue, A. Keating, C.H. Tator, Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience. ,vol. 155, pp. 760- 770 ,(2008) , 10.1016/J.NEUROSCIENCE.2008.05.042
Alison Abbott, Biology's new dimension Nature. ,vol. 424, pp. 870- 872 ,(2003) , 10.1038/424870A
Anne S. Kramer, Alan R. Harvey, Giles W. Plant, Stuart I. Hodgetts, Systematic review of induced pluripotent stem cell technology as a potential clinical therapy for spinal cord injury. Cell Transplantation. ,vol. 22, pp. 571- 617 ,(2013) , 10.3727/096368912X655208
Fabio Zomer Volpato, Tobias Führmann, Claudio Migliaresi, Dietmar W. Hutmacher, Paul D. Dalton, Using extracellular matrix for regenerative medicine in the spinal cord. Biomaterials. ,vol. 34, pp. 4945- 4955 ,(2013) , 10.1016/J.BIOMATERIALS.2013.03.057
Gabsang Lee, Hyesoo Kim, Yechiel Elkabetz, George Al Shamy, Georgia Panagiotakos, Tiziano Barberi, Viviane Tabar, Lorenz Studer, Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells Nature Biotechnology. ,vol. 25, pp. 1468- 1475 ,(2007) , 10.1038/NBT1365
Zahra Taherian Mobarakeh, Jafar Ai, Farzad Yazdani, Seyed Mahdi Rezayat Sorkhabadi, Zinat Ghanbari, Abbas Noroozi Javidan, Seyed AbdolReza Mortazavi‑Tabatabaei, Mohammad Massumi, Somayeh Ebrahimi Barough, Human endometrial stem cells as a new source for programming to neural cells. Cell Biology International Reports. ,vol. 19, pp. 7- 14 ,(2012) , 10.1042/CBR20110009
Xu Jiang, Hao Qing Cao, Li Ya Shi, Shi Yan Ng, Lawrence W. Stanton, Sing Yian Chew, Nanofiber topography and sustained biochemical signaling enhance human mesenchymal stem cell neural commitment. Acta Biomaterialia. ,vol. 8, pp. 1290- 1302 ,(2012) , 10.1016/J.ACTBIO.2011.11.019