Aneuploidies level in sperm nuclei in patients with infertility
作者： Mirzakarim Karimovich Alchinbayev , Araylyim Nugmanovna Aralbayeva , Lazzat Namatullaevna Tuleyeva , Svetlana Melsovna Duysenbayeva , Marat Abzalovich Makazhanov
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摘要: Male infertility is a relevant social and medical problem. mostly caused by genetic disorders. The purpose of the study was to analyze correlation chromosome aberrations, as well DNA fragmentation various manifestations spermatogenesis disorder. Sperm samples 58 males with 23 conditionally healthy were studied. All patients diagnosed asthenozoospermia, teratozoospermia, oligoasthenozoospermia oligoteratozoospermia underwent subsequent analysis sperm fragmentation. examined chromatin dispersion test (sperm dispersion, Spermprocessor, India) an Axioscope 40 fluorescent microscope. Fluorescence in situ hybridization probes (Vysis Multi Vysion PGT, Abbot Molecular) used abnormalities nuclei regard X Y chromosomes, chromosomes 18 21. It found that development pathospermia characterized discontinuity, which manifests disjunction meiosis spermatogenesis. also prevailing type men oligozoospermia. In addition, this group had highest rate numerical abnormalities. This degeneration spermatozoids aneuploidies chromosomes.
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