Method for treatment of prostate cancer and screening of patients benefiting from said method
作者： Kristiina Iljin , Matthias Nees , Mari Björkman , Olli Kallioniemi
DOI:
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摘要: The invention relates to a method for treating ERG-positive prostate cancer patients with an agent counteracting one or more ERG-associated genes and/or manipulating of ERG-related pathways, optionally in combination androgen deprivation therapy. Furthermore, the concerns methods screening which may benefit from said treatment, assessing efficacy therapy patient, progression selecting be tested usefulness treatment cancer, and carcinogenic potential agent.
lens.org 参考文章(8)
Gyorgy Petrovics, Shiv Srivastava, Methods of Diagnosing or Treating Prostate Cancer Using the ERG Gene, Alone or in Combination with Other over or Under Expressed Genes in Prostate Cancer ,(2005)
Randi L. Shand, Edward P. Gelmann, Molecular biology of prostate-cancer pathogenesis. Current Opinion in Urology. ,vol. 16, pp. 123- 131 ,(2006) , 10.1097/01.MOU.0000193384.39351.64
Kristiina Iljin, Maija Wolf, Henrik Edgren, Santosh Gupta, Sami Kilpinen, Rolf I. Skotheim, Mari Peltola, Frank Smit, Gerald Verhaegh, Jack Schalken, Matthias Nees, Olli Kallioniemi, TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. Cancer Research. ,vol. 66, pp. 10242- 10246 ,(2006) , 10.1158/0008-5472.CAN-06-1986
Kari Rostad, Monica Mannelqvist, Ole Halvorsen, Anne Øyan, Trond Bø, Laila Stordrange, Sue Olsen, Svein Haukaas, Biaoyang Lin, Leroy Hood, Inge Jonassen, Lars Akslen, Karl-Henning Kalland, ERG upregulation and related ETS transcription factors in prostate cancer International Journal of Oncology. ,vol. 30, pp. 19- 32 ,(2007) , 10.3892/IJO.30.1.19
S. A. Tomlins, Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer Science. ,vol. 310, pp. 644- 648 ,(2005) , 10.1126/SCIENCE.1117679
A. Subramanian, P. Tamayo, V. K. Mootha, S. Mukherjee, B. L. Ebert, M. A. Gillette, A. Paulovich, S. L. Pomeroy, T. R. Golub, E. S. Lander, J. P. Mesirov, Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 15545- 15550 ,(2005) , 10.1073/PNAS.0506580102
Meletios Verras, Zijie Sun, Roles and regulation of Wnt signaling and β-catenin in prostate cancer Cancer Letters. ,vol. 237, pp. 22- 32 ,(2006) , 10.1016/J.CANLET.2005.06.004
Gyorgy Petrovics, Aijun Liu, Syed Shaheduzzaman, Bungo Furasato, Chen Sun, Yongmei Chen, Martin Nau, Lakshmi Ravindranath, Yidong Chen, Albert Dobi, Vasantha Srikantan, Isabell A Sesterhenn, David G McLeod, Maryanne Vahey, Judd W Moul, Shiv Srivastava, Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome Oncogene. ,vol. 24, pp. 3847- 3852 ,(2005) , 10.1038/SJ.ONC.1208518