A new method for the synthesis of N-protected β-amino-α-keto esters from fluoroalkanesulfonylazides and α-keto esters
作者： Shizheng Zhu , Guifang Jin , Yong Xu
DOI: 10.1016/S0040-4020(03)00622-7
关键词:
摘要: Abstract In the presence of a secondary amine, treatment α-keto esters with fluoroalkanesulfonyl azides at room temperature afforded N -sulfonyl protected β-amino-α-keto in good to excellent yields. This reaction provided novel, direct and convenient access from under mild conditions. However, β-ketoester enamines two products: -fluoroalkanesulfonyl amidines diazoacetate. The mechanism is discussed.
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