Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease.

摘要: The gut-derived hormone fibroblast growth factor 15/19 (FGF15/19) is an emerging versatile regulator of various metabolic pathways. As such, FGF15/19 has been implicated in homeostatic control bile acid, carbohydrate and lipid metabolism multiple target organs including the liver, adipose tissue brain. In line with this, growing evidence suggests that dysregulation contributes to a number acid-associated disorders such as fatty liver disease, Type 2 diabetes different gastrointestinal dysfunctions. this review we summarize current knowledge on organ-specific functions address their underlying molecular mechanisms. Moreover, recent advances characterization factors release gut will be discussed linked view how alterations signaling may contribute disease development. Finally, suitability potential therapeutic critically reviewed.