The Biological Methylation of Metals and Metalloids

摘要: Publisher Summary This chapter discusses the biological methylation of metals and metalloids, their chemical rate studies, other aqueous transmethylations, transmethylation, mechanisms aspects transmethylation. The reaction between ethylcobalamin Hg(OAc) 2 is also reported. Despite importance S-adenosylmethionine in methylation, very little research has been done laboratory on its with arsenic or nor there much effort to explore possible methylsulfur model compounds. For various reasons, and, especially Minamata disaster, most kinetic studies vivo transmethylation have concentrated mercury. An enzyme system isolated from a strain Pseudomonas catalyzes reductive cleavage mercury–carbon linkage methylmercuric Human volunteers who drank wine containing inorganic excreted methylarsonic cacodylic acids urine. At some point during any biotic abiotic, methyl group atom holding it must break. Stereochemical retention configuration around saturated α-carbon can only result closed transition state, whereas open state lead inversion. Water-soluble methylmetals frequently show marked lability undergo facile transformations.