Animal models of Parkinson's disease.

摘要: Animal models of Parkinson’s disease (PD) have been widely used in the past four decades to investigate pathogenesis and pathophysiology this neurodegenerative disorder. These classically based on systemic or local (intracerebral) administration neutoxins that are able replicate most pathological phenotypic features PD mammals (i.e. rodents primates). In last decade, advent ‘genetic era’ has provided a phenomenal enrichment research possibilities field, with development various mammalian (mice and, more recently, rats) non-mammalian transgenic disease-causing mutations identified for monogenic forms familial PD. Both toxic classes animal their own specificities limitations, which must be carefully taken into consideration when choosing model used. If substantial reproducible nigrostriatal lesion is required (e.g. testing therapeutic interventions aimed at counteracting PD-related cell death), classic such as one 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine will adequately serve purpose. On other hand, if selected molecular mechanisms investigated, offer invaluable insights. Therefore, until ‘perfect’ developed, indications use another depend specific objectives being pursued.