Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
作者： Kunimasa Arima , Kenji Uéda , Nobuhiko Sunohara , Shigeo Hirai , Yoko Izumiyama
DOI: 10.1016/S0006-8993(98)00734-3
关键词:
摘要: We examined brains from Parkinson's disease and dementia with Lewy bodies (LBs) by using antibodies to NACP/α-synuclein. Immunohistochemically, all of the against amino-terminal region, NAC domain, carboxyl-terminal region NACP labeled not only LBs, pale (PBs), dystrophic neurites, but also fine thread-like structures in neuronal perikarya (perikaryal threads) hypothalamus brainstem nuclei. On electron microscopy, immunoreactive products were found label 9 12 nm-thick filamentous component (LB-filaments) PBs, perikaryal threads. The NACP-immunoreactive threads, consisting small bundles LB-filaments randomly oriented LB-filaments, presumably represent an initial stage LB- or PB-formation. present study indicates that entire molecule is involved filament-aggregating processes LB disorders.
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