Direct Arylation/Alkylation/Magnesiation of Benzyl Alcohols in the Presence of Grignard Reagents via Ni-, Fe-, or Co-Catalyzed sp3 C–O Bond Activation
作者： Da-Gang Yu , Xin Wang , Ru-Yi Zhu , Shuang Luo , Xiao-Bo Zhang
DOI: 10.1021/JA307045R
关键词:
摘要: Direct application of benzyl alcohols (or their magnesium salts) as electrophiles in various reactions with Grignard reagents has been developed via transition metal-catalyzed sp(3) C-O bond activation. Ni complex was found to be an efficient catalyst for the first direct cross coupling aryl/alkyl reagents, while Fe, Co, or catalysts could promote unprecedented conversion presence (n)hexylMgCl. These methods offer straightforward pathways transform into a variety functionalities.
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