Hormonal and substrate induction of tryptophan pyrrolase in regenerating rat liver.

摘要: The induction of tryptophan pyrrolase by hydrocortisone has been studied in rats following 70% hepatectomy. An alteration the rate was observed both sham-operated and hepatectomized early postoperative period. Normal maximal values were eventually reached, however. Later period, patterns similar to those unoperated rats. During period which DNA synthesis is known occur hepatectomy, depressed but not shamoperated At this latter time l-tryptophan diminished regenerating liver. It suggested other workers that alterations enzyme control mechanisms, such as absolute or relative failure cortisone minimaldeviation hepatomas, may represent a fundamental biochemical tumors. This study shows response hormonal also occurs non-neoplastic hepatic cells preparing divide.