Fabrication of poly(L-lactic acid) porous microspheres via phase inversion emulsion method
作者： Taotao Nie , Li Xue , Min Ge , Haiyun Ma , Jinchao Zhang
关键词:
摘要: Porous microspheres capable of delivering high payloads biomolecules with suitable biodegradability and biocompatibility would be valuable in delivery systems to aid tissue regeneration. In this work, a facile scalable technique was induced prepare poly(L-lactic acid) (PLLA) porous by combining an oil-in-oil surfactant-free phase inversion emulsion thermally separation method. The morphology property the were investigated scanning electron microscopy N2 adsorption test. Comparing conventional biodegradable microspheres, nanoscale topographic structured PLLA may find wide applications biomedical fields.
sci-hub.se 参考文章(12)
Hyun Jung Chung, Tae Gwan Park, Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Advanced Drug Delivery Reviews. ,vol. 59, pp. 249- 262 ,(2007) , 10.1016/J.ADDR.2007.03.015
Nathalie Bock, Maria A. Woodruff, Dietmar W. Hutmacher, Tim R. Dargaville, Electrospraying, a Reproducible Method for Production of Polymeric Microspheres for Biomedical Applications Polymers. ,vol. 3, pp. 131- 149 ,(2011) , 10.3390/POLYM3010131
Yang Hu, Shengwen Zou, Yu Yang, Zhen Tong, Chaoyang Wang, Facile Fabrication of Macroporous PLGA Microspheres via Double‐Pickering Emulsion Templates Macromolecular Chemistry and Physics. ,vol. 216, pp. 714- 720 ,(2015) , 10.1002/MACP.201400574
Dong-Hyun Paik, Sung-Wook Choi, Entrapment of Protein Using Electrosprayed Poly(d,l‐lactide‐co‐glycolide) Microspheres with a Porous Structure for Sustained Release Macromolecular Rapid Communications. ,vol. 35, pp. 1033- 1038 ,(2014) , 10.1002/MARC.201400042
Qingxing Xu, Jiayu Leong, Qi Yi Chua, Yu Tse Chi, Pierce Kah-Hoe Chow, Daniel W. Pack, Chi-Hwa Wang, Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for treatment of human hepatocellular carcinoma. Biomaterials. ,vol. 34, pp. 5149- 5162 ,(2013) , 10.1016/J.BIOMATERIALS.2013.03.044
Jiqing Xu, Yanpeng Jiao, Xiaohong Shao, Changren Zhou, Controlled dual release of hydrophobic and hydrophilic drugs from electrospun poly (l-lactic acid) fiber mats loaded with chitosan microspheres Materials Letters. ,vol. 65, pp. 2800- 2803 ,(2011) , 10.1016/J.MATLET.2011.06.018
Kexin Qiu, Chuanglong He, Wei Feng, Weizhong Wang, Xiaojun Zhou, Zhiqi Yin, Liang Chen, Hongsheng Wang, Xiumei Mo, Doxorubicin-loaded electrospun poly(L-lactic acid)/mesoporous silica nanoparticles composite nanofibers for potential postsurgical cancer treatment Journal of Materials Chemistry B. ,vol. 1, pp. 4601- 4611 ,(2013) , 10.1039/C3TB20636J
Chen Zhao, Ai-Zheng Chen, Shi-Bin Wang, Yuan-Gang Liu, Preparation of MTX–PLLA porous microspheres by a liquid CO2/organic solvent removing process Journal of Controlled Release. ,vol. 172, ,(2013) , 10.1016/J.JCONREL.2013.08.048
Jonny J. Blaker, Jonathan C. Knowles, Richard M. Day, Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery. Acta Biomaterialia. ,vol. 4, pp. 264- 272 ,(2008) , 10.1016/J.ACTBIO.2007.09.011
Ai-Zheng Chen, Chen Zhao, Shi-Bin Wang, Yuan-Gang Liu, Dong-Liang Lin, Generation of porous poly-L-lactide microspheres by emulsion-combined precipitation with a compressed CO2 antisolvent process Journal of Materials Chemistry B. ,vol. 1, pp. 2967- 2975 ,(2013) , 10.1039/C3TB20468E