Biochemical and clinical effects of vitamin E administration in homozygous beta-thalassemia.

摘要: In beta-thalassemic homozygotes, low plasma levels of tocopherols may induce a red blood cell (RBC) lipid peroxidation and consequent hemolysis. This is an indication to treat these patients with vitamin E. this study 26 homozygotes aged 2-14 years, were given E, 10 orally 16 parenterally, 300 mg per day for 15 days. Prior administration transfusion, as compared normal subjects the same age, RBC significantly lower, whereas malonyldialdehyde (MDA) was increased. both groups, after tocopherol administration, increase in decrease MDA found. The significance variations greater parenterally treated group than group. treatment appears be effective reduce oxidative damage homozygous beta-thalassemia, principally when administered perhaps because its poor intestinal absorption subjects.