The Genetic Architecture of Murine Glutathione Transferases
作者： Lu Lu , Ashutosh K. Pandey , M. Trevor Houseal , Megan K. Mulligan
DOI: 10.1371/JOURNAL.PONE.0148230
关键词:
摘要: Glutathione S-transferase (GST) genes play a protective role against oxidative stress and may influence disease risk drug pharmacokinetics. In this study, massive multiscalar trait profiling across large population of mice derived from cross between C57BL/6J (B6) DBA2/J (D2)--the BXD family--was combined with linkage bioinformatic analyses to characterize mechanisms controlling GST expression identify downstream consequences variation. Similar humans, show wide range in family members. Variation the Gsta4, Gstt2, Gstz1, Gsto1, Mgst3 is modulated by local QTLs (eQTLs) several tissues. Higher Gsto1 brain liver strains strongly associated (P < 0.01) inheritance B6 parental allele whereas higher Gsta4 liver, Gstt2 Gstz1 D2 allele. Allele-specific assays confirmed that are sequence variants within or near each gene locus. We exploited endogenous variation coexpression networks targets mouse human. Through systems genetics approach, we provide new insight into biological naturally occurring genes.
doaj.org
harvard.edu
core.ac.uk 参考文章(147)
Ravi J Tolwani, Doug A Hamm, Liqun Tian, J. Daniel Sharer, Jerry Vockley, Piero Rinaldo, Dietrich Matern, Trenton R Schoeb, Philip A Wood, Medium-Chain Acyl-CoA Dehydrogenase Deficiency in Gene-Targeted Mice PLOS Genetics. ,vol. 1, pp. 205- 212 ,(2005) , 10.1371/JOURNAL.PGEN.0010023
E. Y. Bryleva, M. A. Rogers, C. C. Y. Chang, F. Buen, B. T. Harris, E. Rousselet, N. G. Seidah, S. Oddo, F. M. LaFerla, T. A. Spencer, W. F. Hickey, T.-Y. Chang, ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 3081- 3086 ,(2010) , 10.1073/PNAS.0913828107
Magali Dumont, Daniel J. Ho, Noel Y. Calingasan, Hui Xu, Gary Gibson, M. Flint Beal, Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition Free Radical Biology and Medicine. ,vol. 47, pp. 1019- 1027 ,(2009) , 10.1016/J.FREERADBIOMED.2009.07.008
Marie Sanson, Nathalie Augé, Cécile Vindis, Carole Muller, Yoshio Bando, Jean-Claude Thiers, Marie-Agnès Marachet, Kamelija Zarkovic, Yoshiki Sawa, Robert Salvayre, Anne Nègre-Salvayre, Oxidized Low-Density Lipoproteins Trigger Endoplasmic Reticulum Stress in Vascular Cells Prevention by Oxygen-Regulated Protein 150 Expression Circulation Research. ,vol. 104, pp. 328- 336 ,(2009) , 10.1161/CIRCRESAHA.108.183749
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Ellis W.T. Wong, Fumin Chang, Brian Lehmann, David M. Terrian, Michele Milella, Agostino Tafuri, Franca Stivala, Massimo Libra, Jorg Basecke, Camilla Evangelisti, Alberto M. Martelli, Richard A. Franklin, ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE Biochimica et Biophysica Acta. ,vol. 1773, pp. 1263- 1284 ,(2007) , 10.1016/J.BBAMCR.2006.10.001
Lauren M. Aleksunes, Curtis D. Klaassen, Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice Drug Metabolism and Disposition. ,vol. 40, pp. 1366- 1379 ,(2012) , 10.1124/DMD.112.045112
Brian F. Coles, Fabrice Morel, Claudine Rauch, Wolfgang W. Huber, Mihi Yang, Candee H. Teitel, Bridgett Green, Nicholas P. Lang, Fred F. Kadlubar, Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics. ,vol. 11, pp. 663- 669 ,(2001) , 10.1097/00008571-200111000-00004
Xianhong Meng, Yong Liu, Bona Liu, Glutathione S-transferase M1 null genotype meta-analysis on gastric cancer risk. Diagnostic Pathology. ,vol. 9, pp. 122- 122 ,(2014) , 10.1186/1746-1596-9-122
Mohammad Reza Zarrindast, Abolfazl Ardjmand, Shamseddin Ahmadi, Ameneh Rezayof, Activation of dopamine D1 receptors in the medial septum improves scopolamine-induced amnesia in the dorsal hippocampus Behavioural Brain Research. ,vol. 229, pp. 68- 73 ,(2012) , 10.1016/J.BBR.2011.12.033
Sara Piacentini, Renato Polimanti, Rosanna Squitti, Stefania Mariani, Simone Migliore, Fabrizio Vernieri, Paolo Maria Rossini, Dario Manfellotto, Maria Fuciarelli, GSTO1*E155del polymorphism associated with increased risk for late-onset Alzheimer's disease: Association hypothesis for an uncommon genetic variant Neuroscience Letters. ,vol. 506, pp. 203- 207 ,(2012) , 10.1016/J.NEULET.2011.11.005