Preventing diabetic retinopathy by mitigating subretinal space oxidative stress in vivo.

摘要: Patients with diabetes continue to suffer from impaired visual performance before the appearance of overt damage retinal microvasculature and later sight-threatening complications. This diabetic retinopathy (DR) has long been thought start endothelial cell oxidative stress. Yet newer data surprisingly finds that avascular outer retina is primary site stress microvascular histopathology in experimental DR. Importantly, correcting this early sufficient restore vision mitigate models. However, translating these promising results into clinic stymied by an absence methods can measure optimize anti-oxidant treatment efficacy vivo. Here, we review imaging approaches address problem. In particular, diabetes-induced impairs dark-light regulation subretinal space hydration, which regulates distribution interphotoreceptor binding protein (IRBP). IRBP a vision-critical, anti-oxidant, lipid transporter, pro-survival factor. We show how optical coherence tomography thus setting stage for personalizing prevention impactful declines loss patients diabetes.