Retrospective Review of a Prothrombin Complex Concentrate (Beriplex P/N) for the Management of Perioperative Bleeding Unrelated to Oral Anticoagulation

摘要: A multicenter, retrospective, observational study of 4-factor prothrombin complex concentrate (PCC) and/or fresh frozen plasma (FFP) use within routine clinical care unrelated to vitamin K antagonists was conducted. The PCC administered preprocedure for correction coagulopathy (prophylactic cohort) and treatment bleeding postsurgery (treatment cohort). Of the 445 patients included, 40 were in the prophylactic cohort (PCC alone [n ¼ 16], FFP 5], 19]) and 405 228], 123], 54]). Cardiovascular surgery was the most common setting. doses ranged between 500 5000 IU. Effectiveness (assessed retrospectively) reported as effective 93.0% PCC-only group (95% confidence interval, 89.1% 95.9%), 78.9% (70.8% 85.6%) with FFP, and 86.3% (76.2% 93.2%) alone. In cohort, international normalized ratio significantly reduced all 3 groups. who received PCC, rate thromboembolic events (1.9%) below rates literature similar procedures. PCCs offer a potential alternative management perioperative oral anticoagulant therapy.